Development of an experimental model of infected bone void in the ulna of rabbits

نویسندگان

  • Matheus Lemos Azi
  • Mauricio Kfuri Junior
  • Roberto Martinez
  • Luis Antonio Salata
  • Cleber Antonio Jansen Paccola
چکیده

OBJECTIVE Develop a model that allowed the study of bone regeneration in infection conditions. METHOD A 15 mm defect was surgically created in the rabbit ulna and inoculated with 5x10(8) colony-forming units (CFU) of S. aureus. Surgical debridement was performed two weeks after and systemic gentamicin was administered for four weeks. Animals were followed up to 12 weeks to evaluate infection control and bone regeneration. RESULT Bone regeneration was inferior to 25% of the defect in radiological and histological analysis. CONCLUSION Infected bone defect of 15 mm in the rabbit ulna was unable to achieve full regeneration without further treatment. Level of Evidence V, Experimental Study.

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عنوان ژورنال:

دوره 20  شماره 

صفحات  -

تاریخ انتشار 2012